The short answer
They stop treating the timezone gap as a staffing problem and treat it as a product requirement. The winners front-load everything a new user could possibly need into the product itself, docs, sample data, an in-product help layer, so the answer is there at 2am in San Francisco without a person. Chargebee, Postman, Freshworks and Zoho all built self-serve depth for exactly this reason, and it turned out to be the cost advantage rather than a compromise. Where humans are unavoidable, run one deliberate overlap window rather than pretending to cover 24 hours badly, and be explicit about it, because a stated four hour window beats an unreliable promise of always-on. The India edge here is real: a self-serve funnel acquires global customers at a structurally lower cost than a US sales floor.